Clinical diagnosis | Molecular genetics | Services

Group/Abbrev.	Name/Type of alteration	Method/Genes	Notes	Manufacturer
Cervical screening
	HPV test	Aptima / Alinity	clinically relevant copy numbers	Hologic/Abbott
	Qiasure test	Methylation analysis of selected tumor supressor genes		Qiagen
	STI7	7 sexually transmitted organisms	LOD ≥100 organisms/reaction	Seegene
	Genital ulcer	Herpes virus 1 and 2, CMV, Varicella-zoster virus, Haemophilus ducreyi, Lymphogranuloma venereum, Treponema pallidum	LOD ≥100 organisms/reaction	Seegene
	Candidosis	Candida albicans, C. krusei, C. glabrata, C. dubliniensis, C. parapsilosis, C. tropicalis, C. lusitaniae	LOD ≥100 organisms/reaction	Seegene
	Vaginitis screening	Quantitative detection of Lactobacillus spp., G. vaginalis, A. vaginae, qualitative detection of Mobiluncus spp., Trichomonas vaginalis,Candida albicans, Candida spp.	LOD ≥100 organisms/reaction	Seegene

Dry stool collection
	Gastrointestinal pathogens - viruses	Norovirus GI, Norovirus GII, Rotavirus, Adenovirus, Astrovirus, Sapovirus - Real Time PCR, MuDT technology	LOD ≥100 organisms/reaction	Seegene
	Gastrointestinal pathogens - bacteria I	Campylobacter spp., Clostridium difficile toxin B, Salmonella spp., EIEC*/Shigella spp., Vibrio spp. , Yersinia enterocolitica, Aeromonas spp. - Real Time PCR, MuDT technology	LOD ≥100 organisms/reaction	Seegene
	Gastrointestinal pathogens - bacteria II	Clostridium difficile, E. coli O157, EHEC E. coli ( stx1/2 ), EPEC E. coli ( eaeA ), ETEC-E. coli ( It/st ), EAEC E. coli ( aggR ) - Real Time PCR, MuDT technology	LOD ≥100 organisms/reaction	Seegene
	Gastrointestinal pathogens - helmintes	Ancylostoma spp., Ascaris spp., Enterobius vermicularis, Enterocytozoon spp. / Encephalitozoon spp., Hymenolepis spp., Necator americanus, Strongyloides spp., Taenia spp., Trichuris trichiura - Real Time PCR, MuDT technology	LOD ≥100 organisms/reaction	Seegene
	Gastrointestinal pathogens - parasites	Giardia lamblia, Entamoeba histolytica, Cryptosporidium spp., Blastocystis hominis, Dientamoeba fragilis, Cyclospora cayetanensis - Real Time PCR, MuDT technology	LOD ≥100 organisms/reaction	Seegene

Mutation analysis, fusion transcript analysis, CNV analysis, clonality analysis, microbiom analysis, expression analysis by NGS
Next generation sequencing (NGS)

EXOM seq SOMATIC	Somatic mutation	Analysis of 1000 cancer related genes using Twist Exome 2.0 kit with avrg. read depth 500x.		Twist
	Mutation - somatic	ABCB1, ABI1, ABL1, ABL2, ABRAXAS1, ACKR3, ACSL3, ACSL6, ACTB, ACTG1, ACVR1, ACVR1B, ACVR2A, ADARB2, ADGRA2, ADGRG4, ADHFE1, AFDN, AFF1, AFF3, AFF4, AGGF1, AGK, AGO1, AGO2, AIP, AJUBA, AKT1, AKT1S1, AKT2, AKT3, ALB, ALDH1L2, ALDH2, ALK, ALOX12B, ALOX15B, ALOX5, AMER1, ANKRD11, ANKRD26, APC, APEX1, APH1A, APLNR, APOBEC3B, AR, ARAF, ARFRP1, ARHGAP26, ARHGAP35, ARHGEF12, ARHGEF28, ARID1A, ARID1B, ARID2, ARID3A, ARID3B, ARID3C, ARID4A, ARID4B, ARID5A, ARID5B, ARNT, ASMTL, ASPSCR1, ASXL1, ASXL2, ATF1, ATG5, ATIC, ATM, ATP1A1, ATP2B3, ATP6AP1, ATP6V1B2, ATR, ATRIP, ATRX, ATXN2, ATXN7, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, BAALC, BABAM1, BACH2, BAP1, BARD1, BAX, BBC3, BCL10, BCL11A, BCL11B, BCL2, BCL2L1, BCL2L11, BCL2L2, BCL3, BCL6, BCL7A, BCL9, BCL9L, BCOR, BCORL1, BCR, BIRC3, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRD3, BRD4, BRIP1, BRSK1, BTG1, BTG2, BTK, BTLA, BUB1B, CACNA1D, CAD, CALR, CAMTA1, CANT1, CARD11, CARM1, CARS1, CASP8, CASR, CBFA2T3, CBFB, CBL, CBLB, CBLC, CCDC6, CCN6, CCNB1IP1, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNQ, CCT6B, CD19, CD22, CD274, CD276, CD28, CD36, CD58, CD70, CD74, CD79A, CD79B, CDC42, CDC73, CDH1, CDH11, CDH2, CDH4, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDX2, CEBPA, CENPA, CEP43, CIC, CIITA, CILK1, CKS1B, CLIP1, CLP1, CLTC, CLTCL1, CMTR2, CNBP, CNOT3, CNTRL, COL1A1, COL2A1, COP1, CPS1, CRBN, CREB1, CREB3L1, CREB3L2, CREBBP, CREM, CRKL, CRLF2, CRTC1, CRTC3, CSDE1, CSF1, CSF1R, CSF3R, CTC1, CTCF, CTDNEP1, CTLA4, CTNNA1, CTNNB1, CTR9, CUL3, CUL4A, CUX1, CXCR4, CYLD, CYP17A1, CYP19A1, CYSLTR2, DAXX, DAZAP1, DCTN1, DCUN1D1, DDB2, DDIT3, DDR1, DDR2, DDX10, DDX3X, DDX4, DDX41, DDX5, DDX6, DEK, DHX15, DICER1, DIS3, DIS3L2, DKK1, DKK2, DKK3, DKK4, DNAJB1, DNM2, DNMT1, DNMT3A, DNMT3B, DOT1L, DPYD, DROSHA, DTX1, DUSP2, DUSP22, DUSP4, DUSP9, E2F3, EBF1, ECSIT, ECT2L, EED, EGFL7, EGFR, EGR1, EGR2, EIF1AX, EIF2B1, EIF3E, EIF4A2, EIF4E, ELF3, ELF4, ELK4, ELL, ELL2, ELN, ELOC, ELP2, EML4, EMSY, EP300, EP400, EPAS1, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, EPHB4, EPOR, EPS15, ERBB2, ERBB3, ERBB4, ERC1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERF, ERG, ERRFI1, ESCO2, ESR1, ETAA1, ETNK1, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EXOSC6, EXT1, EXT2, EZH1, EZH2, EZHIP, EZR, FAF1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FAT4, FBXO11, FBXO31, FBXW2, FBXW7, FCGR2B, FCRL4, FES, FEV, FGF1, FGF10, FGF12, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FH, FHIT, FIP1L1, FLCN, FLI1, FLT1, FLT3, FLT4, FLYWCH1, FNBP1, FOLH1, FOLR1, FOXA1, FOXF1, FOXL2, FOXN4, FOXO1, FOXO3, FOXO4, FOXP1, FRS2, FSTL1, FSTL3, FUBP1, FURIN, FUS, FYN, FZR1, GAB1, GAB2, GABRA6, GADD45B, GAS7, GATA1, GATA2, GATA3, GATA4, GATA6, GEN1, GID4, GLI1, GMPS, GNA11, GNA12, GNA13, GNAQ, GNAS, GNB1, GOLGA5, GOPC, GPC3, GPHN, GPS2, GRB7, GREM1, GRIN2A, GRM3, GSK3B, GSTP1, GTF2I, GTSE1, H1-2, H1-3, H1-4, H1-5, H2AC11, H2AC16, H2AC17, H2AC6, H2BC11, H2BC12, H2BC17, H2BC4, H2BC5, H2BC8, H3-3A, H3-3B, H3-4, H3-5,	LOD 5 %
	Mutation - somatic	H3C1, H3C10, H3C11, H3C12, H3C13, H3C14, H3C15, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3P6, H4C6, H4C9, HDAC1, HDAC2, HDAC4, HDAC7, HERPUD1, HEY1, HFE, HGF, HIF1A, HIP1, HIRA, HLA-A, HLA-B, HLA-C, HLF, HMGA1, HMGA2, HNF1A, HNF1B, HNRNPA2B1, HOOK3, HOXA11, HOXA13, HOXA3, HOXA9, HOXB13, HOXC11, HOXC13, HOXD11, HOXD13, HRAS, HSD17B2, HSD3B1, HSP90AA1, HSP90AB1, HTATIP2, CHD2, CHD4, CHEK1, CHEK2, CHCHD7, CHIC2, CHN1, CHTF8, ICOSLG, ID1, ID3, IDH1, IDH2, IFNAR1, IFNGR1, IGF1, IGF1R, IGF2, IGH, IGK, IGL, IKBKB, IKBKE, IKZF1, IKZF2, IKZF3, IL10, IL2, IL21R, IL3, IL6ST, IL7R, ING1, INHA, INHBA, INPP4A, INPP4B, INPP5D, INPPL1, INSR, INTS6, IQGAP1, IRF1, IRF2, IRF4, IRF8, IRS1, IRS2, IRS4, ITK, ITPKB, JAK1, JAK2, JAK3, JARID2, JAZF1, JUN, KAT6A, KAT6B, KAT7, KBTBD4, KCNJ5, KDM2B, KDM4C, KDM5A, KDM5C, KDM5D, KDM6A, KDR, KDSR, KEAP1, KEL, KIAA1549, KIF5B, KIT, KLF2, KLF3, KLF4, KLF5, KLF6, KLHL6, KLK2, KMT2A, KMT2B, KMT2C, KMT2D, KMT5A, KNL1, KNSTRN, KRAS, KSR2, KTN1, LARP4B, LASP1, LATS1, LATS2, LCK, LCP1, LEF1, LGR5, LIFR, LMNA, LMO1, LMO2, LPP, LRIG3, LRP1B, LRP5, LRP6, LRRK2, LTB, LTK, LYL1, LYN, LZTR1, MAD2L2, MAF, MAFB, MAGED1, MAGI2, MAL2, MALT1, MAML2, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAP3K14, MAP3K21, MAP3K6, MAP3K7, MAP4K4, MAPK1, MAPK3, MAPKAP1, MAX, MBD4, MBD6, MCL1, MDC1, MDM2, MDM4, MDS2, MECOM, MED12, MEF2B, MEF2C, MEF2D, MEN1, MERTK, MET, MGA, MGAM, MIB1, MIDEAS, MITF, MKI67, MKNK1, MLF1, MLH1, MLH3, MLLT1, MLLT10, MLLT11, MLLT3, MLLT6, MN1, MNX1, MOB3B, MPEG1, MPL, MRE11, MRTFA, MS4A1, MSH2, MSH3, MSH6, MSI1, MSI2, MSN, MST1, MST1R, MTAP, MTCP1, MTHFD2, MTHFR, MTOR, MUC1, MUTYH, MYB, MYBL1, MYC, MYCL, MYCN, MYD88, MYH11, MYH9, MYO18A, MYO5A, MYOD1, NAB2, NACA, NADK, NBEAP1, NBN, NCOA1, NCOA2, NCOA3, NCOA4, NCOR1, NCOR2, NCSTN, NDRG1, NEGR1, NF1, NF2, NFATC2, NFE2, NFE2L2, NFIB, NFKB2, NFKBIA, NFKBIE, NHERF1, NIN, NKX2-1, NKX3-1, NOD1, NONO, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NQO1, NR4A3, NRAS, NRG1, NSD1, NSD2, NSD3, NT5C2, NTHL1, NTRK1, NTRK2, NTRK3, NUF2, NUMA1, NUP214, NUP93, NUP98, NUTM1, NUTM2A, NUTM2B, NUTM2D, OLIG2, OMD, ONECUT2, P2RY8, PAFAH1B2, PAG1, PAK1, PAK3, PAK5, PALB2, PARP1, PARP2, PARP3, PASK, PATZ1, PAX3, PAX5, PAX7, PAX8, PBRM1, PBX1, PC, PCBP1, PCLO, PCM1, PCSK7, PDCD1, PDCD11, PDCD1LG2, PDE4DIP, PDGFB, PDGFRA, PDGFRB, PDK1, PDPK1, PDS5B, PER1, PGBD5, PGR, PHF1, PHF19, PHF6, PHLPP1, PHLPP2, PHOX2B, PICALM, PIGA, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLAG1, PLCG1, PLCG2, PLK2, PMAIP1, PML, PMS1, PMS2, PNRC1, POLD1, POLE, POLG, POLH, POLQ, POT1, POU2AF1, POU2F2, POU3F2, POU3F4, POU5F1, PPARG, PPFIBP1, PPM1D, PPP1CB, PPP2R1A, PPP2R2A, PPP4R2, PPP6C, PRCC, PRDM1, PRDM14, PRDM16, PREX2, PRF1, PRKACA, PRKAR1A, PRKCB, PRKCI, PRKD1, PRKDC, PRKN, PRPF8, PRRX1, PRSS1, PRSS8, PSIP1, PSMB2, PTEN, PTCH1, PTK6, PTK7, PTP4A1, PTPN1, PTPN11, PTPN13, PTPN14, PTPN2, PTPN6, PTPRB, PTPRC, PTPRD, PTPRK, PTPRO, PTPRS, PTPRT, PUM1, QKI, RAB35, RABEP1, RAC1, RAC2, RAD17, RAD21,
	Mutation - somatic	RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RALGDS, RANBP2, RAP1GDS1, RARA, RASA1, RASGEF1A, RB1, RBM10, RBM15, RECQL, RECQL4, REL, RELN, REST, RET, REV3L, RHEB, RHOA, RHOH, RICTOR, RIOK2, RIT1, RMI2, RNASEH2A, RNASEH2B, RNF213, RNF217-AS1, RNF43, ROBO1, ROS1, RPL10, RPL22, RPL5, RPN1, RPS15, RPS6KA4, RPS6KB1, RPS6KB2, RPTOR, RRAGC, RRAS, RRAS2, RSPO2, RSPO3, RTEL1, RUNX1, RUNX1T1, RUNX2, RXRA, RYBP, S1PR2, SALL4, SAMD9, SAMD9L, SAMHD1, SBDS, SCG5, SDC4, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC31A, SEPTIN5, SEPTIN6, SEPTIN9, SERP2, SERPINB3, SERPINB4, SESN1, SESN2, SESN3, SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETDB1, SETDB2, SF3B1, SF3B2, SFPQ, SFRP1, SFRP2, SFRP4, SGK1, SH2B3, SH2D1A, SH3GL1, SHOC2, SHQ1, SIX1, SLC1A2, SLC34A2, SLC45A3, SLFN11, SLIT2, SLIT3, SLX4, SMAD2, SMAD3, SMAD4, SMARCA1, SMARCA2, SMARCA4, SMARCB1, SMARCD1, SMARCE1, SMC1A, SMC3, SMG1, SMO, SMYD3, SNCAIP, SND1, SNX29, SOCS1, SOCS2, SOCS3, SOS1, SOX10, SOX17, SOX2, SOX9, SP140, SPEN, SPOP, SPRED1, SPRTN, SQSTM1, SRC, SRP72, SRSF2, SRSF3, SS18, SS18L1, SSX1, SSX2, SSX4, STAG1, STAG2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STIL, STK11, STK19, STK40, STRN, SUFU, SUZ12, SYK, SZT2, TACSTD2, TAF1, TAF15, TAL1, TAL2, TAP1, TAP2, TBL1XR1, TBX3, TCEA1, TCF12, TCF3, TCF7L2, TCL1A, TCL1B, TEC, TEK, TENT5C, TERC, TERT, TET1, TET2, TET3, TFE3, TFEB, TFG, TFPT, TFRC, TGFBR1, TGFBR2, TIGAR, TIPARP, TLE1, TLE2, TLE3, TLE4, TLL2, TLX1, TLX3, TMEM127, TMEM30A, TMPRSS2, TMSB4XP8, TNFAIP3, TNFRSF11A, TNFRSF14, TNFRSF17, TNFSF13, TONSL, TOP1, TOP2A, TP53, TP53BP1, TP63, TPM3, TPM4, TPMT, TPR, TRA, TRAF2, TRAF3, TRAF5, TRAF7, TRB, TRD, TRG, TRIB3, TRIM24, TRIM27, TRIM33, TRIP11, TRIP13, TRRAP, TSC1, TSC2, TSHR, TTL, TUSC3, TYK2, TYMS, TYRO3, U2AF1, U2AF2, UBA1, UBE2A, UBR5, UBTF, UCHL1, UPF1, USP1, USP6, USP8, VAV1, VAV2, VEGFA, VHL, VTCN1, WAS, WDCP, WDR90, WEE1, WIF1, WRN, WT1, WWP1, WWTR1, XBP1, XIAP, XPA, XPC, XPO1, XRCC1, XRCC2, YAP1, YES1, YPEL5, YWHAE, YY1, YY1AP1, ZBTB16, ZBTB20, ZBTB7A, ZFHX3, ZFP36L1, ZFP36L2, ZMYM2, ZMYM3, ZNF217, ZNF24, ZNF292, ZNF331, ZNF384, ZNF521, ZNF703, ZNF750, ZNRF3, ZRSR2
	other genes mutation - somatic: individualy on request	any of remaining genes

RNA seq - Whole Transcriptome sequencing		Fusion detection and expression across whole transcriptome using RNA sequencing	Currently under validation	Twist

EXOM seq GERMLINE	Germline - SOPHiA Whole Exome Solution v2		LOD NA	Sophia Genetics
	Mutation - germline (226 cancer related genes)	AIP, ALK, APC, APEX1, ATM, ATMIN, ATR, ATRIP, AURKA, AXIN1, BABAM1, BAP1, BARD1, BLM, BMPR1A, BRAP, BRCA1, BRCA2, BRCC3, BRE, BRIP1, BUB1B, C11orf30, C19orf40, casp8, CCND1, CDC73, CDH1, CDK4, CDKN1B, CDKN1C, CDKN2A, CEBPA, CEP57, CLSPN, CSNK1D, CSNK1E, CWF19L2, CYLD, DCLRE1C, DDB2, DHFR, DICER1, DIS3L2, DMBT1, DMC1, DNAJC21, DPYD, EGFR, EPCAM, EPHX1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ESR1, ESR2, EXO1, EXT1, EXT2, EYA2, EZH2, FAM175A, FAM175B, FAN1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FBXW7, FH, FLCN, GADD45A, GATA2, GPC3, GRB7, HELQ, HNF1A, HOXB13, HRAS, HUS1, CHEK1, CHEK2, KAT5, KCNJ5, KIT, LIG1, LIG3, LIG4, LMO1, LRIG1, MAX, MCPH1, MDC1, MDM2, MDM4, MEN1, MET, MGMT, MLH1, MLH3, MMP8, MPL, MRE11A, MSH2, MSH3, MSH5, MSH6, MSR1, MUS81, MUTYH, NAT1, NBN, NCAM1, NELFB, NF1, NF2, NFKBIZ, NHEJ1, NSD1, OGG1, PALB2, PARP1, PCNA, PHB, PHOX2B, PIK3CG, PLA2G2A, PMS1, PMS2, POLB, POLD1, POLE, PPM1D, PREX2, PRF1, PRKAR1A, PRKDC, PTEN, PTCH1, PTTG2, RAD1, RAD17, RAD18, RAD23B, RAD50, RAD51, RAD51AP1, RAD51B, RAD51C, RAD51D, RAD52, RAD54B, RAD54L, RAD9A, RB1, RBBP8, RECQL, RECQL4, RECQL5, RET, RFC1, RFC2, RFC4, RHBDF2, RNF146, RNF168, RNF8, RPA1, RUNX1, SBDS, SDHA, SDHAF2, SDHB, SDHC, SDHD, SETBP1, SETX, SHPRH, SLX4, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TCL1A, TELO2, TERF2, TERT, TLR2, TLR4, TMEM127, TOPBP1, TP53, TP53BP1, TSC1, TSC2, TSHR, UBE2A, UBE2B, UBE2I, UBE2V2, UBE4B, UIMC1, VHL, WRN, WT1, XPA, XPC, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, ZNF350, ZNF365
	CNV - germline (selected genes)	ATM, APC, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, ABRAXAS1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PIK3CA, PMS2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, XRCC2
	other genes mutation - germline: individualy on request	any of remaining genes

OncoDEEP	OncoDeep 638 genes DNA somatic mutation kit with additional biomarkers MSI, TMB, HRD.			OncoDNA
	Mutation - somatic	ABL1 ,BABAM1 ,CD79B ,CXCR4 ,EPHB1 ,FGF10 ,GEN1 ,HNRNPK ,ABL2 ,BAP1 ,CDC42 ,CYLD ,EPHB4 ,FGF12 ,GID4 ,HOXB13 ,ACVR1 ,BARD1 ,CDC73 ,CYP17A1 ,ERBB2 ,FGF14 ,GLI1 ,HRAS ,ACVR1B ,BBC3 ,CDH1 ,CYP19A1 ,ERBB3 ,FGF19 ,GNA11 ,HSD3B1 ,ADARB2 ,BCL10 ,CDH4 ,CYP2C19 ,ERBB4 ,FGF2 ,GNA13 ,HSP90AA1 ,AGO1 ,BCL2 ,CDK12 ,CYP2D6 ,ERCC1 ,FGF23 ,GNAQ ,ICOSLG ,AGO2 ,BCL2L1 ,CDK4 ,CYSLTR2 ,ERCC2 ,FGF3 ,GNAS ,ID3 ,AJUBA ,BCL2L11 ,CDK6 ,DAXX ,ERCC3 ,FGF4 ,GNB1 ,IDH1 ,AKT1 ,BCL2L2 ,CDK7 ,DCUN1D1 ,ERCC4 ,FGF5 ,GPR124 ,IDH2 ,AKT2 ,BCL6 ,CDK8 ,DDR1 ,ERCC5 ,FGF6 ,GPS2 ,IFNGR1 ,AKT3 ,BCOR ,CDKN1A ,DDR2 ,ERF ,FGF7 ,GREM1 ,IGF1 ,ALB ,BCORL1 ,CDKN1B ,DDX41 ,ERG ,FGF8 ,GRIN2A ,IGF1R ,ALK ,BCR ,CDKN2A ,DHX15 ,ERRFI1 ,FGF9 ,GRM3 ,IGF2 ,ALOX12B ,BIRC3 ,CDKN2B ,DICER1 ,ESR1 ,FGFR1 ,GSK3B ,IKBKE ,AMER1 ,BLM ,CDKN2C ,DIS3 ,ETAA1 ,FGFR2 ,H3F3A ,IKZF1 ,ANKRD11 ,BMPR1A ,CEBPA ,DNAJB1 ,ETS1 ,FGFR3 ,H3F3B ,IL10 ,ANKRD26 ,BRAF ,CENPA ,DNMT1 ,ETV1 ,FGFR4 ,H3F3C ,IL7R ,APC ,BRCA1 ,CHD2 ,DNMT3A ,ETV4 ,FH ,HDAC1 ,INHA ,APLNR ,BRCA2 ,CHD4 ,DNMT3B ,ETV5 ,FLCN ,HGF ,INHBA ,AR ,BRD4 ,CHEK1 ,DOT1L ,ETV6 ,FLI1 ,HIST1H1C ,INPP4A ,ARAF ,BRIP1 ,CHEK2 ,DPYD ,EWSR1 ,FLT1 ,HIST1H2BD ,INPP4B ,ARFRP1 ,BTG1 ,CIC ,DROSHA ,EZH1 ,FLT3 ,HIST1H3A ,INPPL1 ,ARHGAP35 ,BTG2 ,CMTR2 ,DUSP4 ,EZH2 ,FLT4 ,HIST1H3B ,INSR ,ARID1A ,BTK ,CNTN4 ,E2F3 ,EZR ,FOXA1 ,HIST1H3C ,IRF2 ,ARID1B ,CALR ,CREBBP ,EED ,FAM175A ,FOXF1 ,HIST1H3D ,IRF4 ,ARID2 ,CARD11 ,CRKL ,EGFL7 ,FAM46C ,FOXL2 ,HIST1H3E ,IRS1 ,ARID5B ,CARM1 ,CRLF2 ,EGFR ,FAM58A ,FOXO1 ,HIST1H3F ,IRS2 ,ASXL1 ,CASP8 ,CSDE1 ,EIF1AX ,FANCA ,FOXP1 ,HIST1H3G ,JAK1 ,ASXL2 ,CBFB ,CSF1R ,EIF4A2 ,FANCC ,FRS2 ,HIST1H3H ,JAK2 ,ATM ,CBL ,CSF3R ,EIF4E ,FANCD2 ,FUBP1 ,HIST1H3I ,JAK3 ,ATR ,CCNB3 ,CSNK1A1 ,ELF3 ,FANCE ,FYN ,HIST1H3J ,JUN ,ATRX ,CCND1 ,CTCF ,EML4 ,FANCF ,GAB1 ,HIST2H3A ,KAT6A ,ATXN7 ,CCND2 ,CTLA4 ,EMSY ,FANCG ,GAB2 ,HIST2H3C ,KBTBD4 ,AURKA ,CCND3 ,CTNNA1 ,EP300 ,FANCI ,GABRA6 ,HIST2H3D ,KDM5A ,AURKB ,CCNE1 ,CTNNB1 ,EPAS1 ,FANCL ,GATA1 ,HIST3H3 ,KDM5C ,AXIN1 ,CD276 ,CTR9 ,EPCAM ,FAS ,GATA2 ,HLA-A ,KDM6A ,AXIN2 ,CD70 ,CUL3 ,EPHA3 ,FAT1 ,GATA3 ,HLA-B ,KDR ,AXL ,CD74 ,CUL4A ,EPHA5 ,FBXW7 ,GATA4 ,HLA-C ,KEAP1 ,B2M ,CD79A ,CUX1 ,EPHA7 ,FGF1 ,GATA6 ,HNF1A ,KEL ,KIF5B ,KIT ,KLF4 ,KLF5 ,KLHL6 ,KMT2A ,KMT2B ,KMT2C ,KMT2D ,KMT5A ,KNSTRN ,KRAS ,LAMP1 ,LATS1 ,LATS2 ,LMO1 ,LRP1B ,LTK ,LYN ,LZTR1 ,MAD2L2 ,MAGI2 ,MALT1 ,MAP2K1 ,MAP2K2 ,MAP2K4 ,MAP3K1 ,MAP3K13 ,MAP3K14 ,MAP3K4 ,MAPK1 ,MAPK3 ,MAPKAP1 ,MAX ,MCL1 ,MDC1 ,MDM2 ,MDM4 ,MED12 ,MEF2B ,MEN1 ,MET ,MGA ,MITF ,MLH1 ,MLLT1 ,MLLT3 ,MPL ,MRE11A ,MSH2 ,MSH3 ,MSH6 ,MSI1 ,MSI2 ,MST1 ,MST1R ,MTAP ,MTOR ,MUTYH ,MYB ,MYC ,MYCL ,MYCN ,MYD88 ,MYOD1 ,NAB2 ,NADK ,NBN ,NCOA3 ,NCOR1 ,NEGR1 ,NF1 ,NF2 ,NFE2L2 ,NFKBIA ,NKX2-1 ,NKX3-1 ,NOTCH1 ,NOTCH2 ,NOTCH3 ,NOTCH4 ,NPM1 ,NRAS ,NRG1 ,NSD1 ,NT5C2 ,NTHL1 ,NTRK1 ,NTRK2 ,NTRK3 ,NUF2 ,NUP93 ,NUTM1 ,OPCML ,P2RY8 ,PAK1 ,PAK3 ,PAK7 ,PALB2 ,PARK2 ,PARP1 ,PARP2 ,PARP3 ,PAX3 ,PAX5 ,PAX7 ,PAX8 ,PBRM1 ,PD-1 ,PD-L1 ,PD-L2 ,PDGFRA ,PDGFRB ,PDK1 ,PDPK1 ,PGBD5 ,PGR ,PHF6 ,PHOX2B ,PIGA ,PIK3C2B ,PIK3C2G ,PIK3C3 ,PIK3CA ,PIK3CB ,PIK3CD ,PIK3CG ,PIK3R1 ,PIK3R2 ,PIK3R3 ,PIM1 ,PLCG2 ,PLK2 ,PMAIP1 ,PMS1 ,PMS2 ,PNRC1 ,POLD1 ,POLE ,POT1 ,PPARG ,PPM1D ,PPP2R1A ,PPP2R2A ,PPP4R2 ,PPP6C ,PRDM1 ,PRDM14 ,PREX2 ,PRKAR1A ,PRKCI ,PRKD1 ,PRKDC ,PRSS8 ,PTCH1 ,PTEN ,PTP4A1 ,PTPN11 ,PTPRD ,PTPRN2 ,PTPRS ,PTPRT ,QKI ,RAB35 ,RAC1 ,RAC2 ,RAD21 ,RAD50 ,RAD51 ,RAD51B ,RAD51C ,RAD51D ,RAD52 ,RAD54L ,RAF1 ,RANBP2 ,RARA ,RASA1 ,RB1 ,RBM10 ,RECQL ,RECQL4 ,REL ,REST ,RET ,RFWD2 ,RHEB ,RHOA ,RICTOR ,RIT1 ,RNF43 ,ROS1 ,RPS6KA4 ,RPS6KB1 ,RPS6KB2 ,RPTOR ,RRAGC ,RRAS ,RRAS2 ,RSPO2 ,RTEL1 ,RUNX1 ,RUNX1T1 ,RXRA ,RYBP ,SCG5 ,SDC4 ,SDHA ,SDHAF2 ,SDHB ,SDHC ,SDHD ,SERPINB3 ,SERPINB4 ,SESN1 ,SESN2 ,SESN3 ,SETBP1 ,SETD2 ,SETDB1 ,SF3B1 ,SGK1 ,SH2B3 ,SH2D1A ,SHOC2 ,SHQ1 ,SLC34A2 ,SLFN11 ,SLIT2 ,SLX4 ,SMAD2 ,SMAD3 ,SMAD4 ,SMARCA2 ,SMARCA4 ,SMARCB1 ,SMARCD1 ,SMARCE1 ,SMC1A ,SMC3 ,SMO ,SMYD3 ,SNCAIP ,SNTG2 ,SOCS1 ,SOS1 ,SOX10 ,SOX17 ,SOX2 ,SOX9 ,SPEN ,SPOP ,SPRED1 ,SPRTN ,SPTA1 ,SRC ,SRSF2 ,STAG1 ,STAG2 ,STAT3 ,STAT4 ,STAT5A ,STAT5B ,STK11 ,STK19 ,STK40 ,SUFU ,SUZ12 ,SYK ,TAF1 ,TAP1 ,TAP2 ,TBX3 ,TCEB1 ,TCF3 ,TCF7L2 ,TEK ,TERT ,TET1 ,TET2 ,TFE3 ,TFRC ,TGFBR1 ,TGFBR2 ,TIPARP ,TMEM127 ,TMPRSS2 ,TNFAIP3 ,TNFRSF14 ,TOP1 ,TOP2A ,TP53 ,TP53BP1 ,TP63 ,TPMT ,TRAF2 ,TRAF7 ,TRIP13 ,TSC1 ,TSC2 ,TSHR ,TYRO3 ,U2AF1 ,UGT1A1 ,UPF1 ,USP8 ,VEGFA ,VHL ,VTCN1 ,WHSC1 ,WHSC1L1 ,WISP3 ,WT1 ,WWTR1 ,XIAP ,XPO1 ,XRCC2 ,YAP1 ,YES1 ,ZBTB2 ,ZBTB7A ,ZFHX3 ,ZNF217 ,ZNF703 ,ZNRF3 ,ZRSR2	LOD 5 %, Tumor Mutation Burden, MSI status, HRD status

TS500D, TS500R	TSO500 complete DNA mutation and RNA fusion analysis			Illumina
	Mutation - somatic	ABL1, ABL2, ACVR1, ACVR1B, AKT1, AKT2, AKT3, ALK, ALOX12B, ANKRD11, ANKRD26, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, BAP1, BARD1, BBC3, BCL10, BCL2, BCL2L1, BCL2L11, BCL2L2, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTK, C11orf30, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD274, CD276, CD74, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CENPA, CHD2, CHD4, CHEK1, CHEK2, CIC, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CSNK1A1, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CUX1, CXCR4, CYLD, DAXX, DCUN1D1, DDR2, DDX41, DHX15, DICER1, DIS3, DNAJB1, DNMT1, DNMT3A, DNMT3B, DOT1L, E2F3, EED, EGFL7, EGFR, EIF1AX, EIF4A2, EIF4E, EML4, EP300, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERG, ERRFI1, ESR1, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EZH2, FAM123B, FAM175A, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FAS, FAT1, FBXW7, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLI1, FLT1, FLT3, FLT4, FOXA1, FOXL2, FOXO1, FOXP1, FRS2, FUBP1, FYN, GABRA6, GATA1, GATA2, GATA3, GATA4, GATA6, GEN1, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GPR124, GPS2, GREM1, GRIN2A, GRM3, GSK3B, H3F3A, H3F3B, H3F3C, HGF, HIST1H1C, HIST1H2BD, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST2H3A, HIST2H3C, HIST2H3D, HIST3H3, HLA-A, HLA-B, HLA-C, HNF1A, HNRNPK, HOXB13, HRAS, HSD3B1, HSP90AA1, ICOSLG, ID3, IDH1, IDH2, IFNGR1, IGF1, IGF1R, IGF2, IKBKE, IKZF1, IL10, IL7R, INHA, INHBA, INPP4A, INPP4B, INSR, IRF2, IRF4, IRS1, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIF5B, KIT, KLF4, KLHL6, KMT2B, KMT2C, KMT2D, KRAS, LAMP1, LATS1, LATS2, LMO1, LRP1B, LYN, LZTR1, MAGI2, MALT1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAP3K14, MAP3K4, MAPK1, MAPK3, MAX, MCL1, MDC1, MDM2, MDM4, MED12, MEF2B, MEN1, MET, MGA, MITF, MLH1, MLL, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MST1, MST1R, MTOR, MUTYH, MYB, MYC, MYCL1, MYCN, MYD88, MYOD1, NAB2, NBN, NCOA3, NCOR1, NEGR1, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NKX3-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NRG1, NSD1, NTRK1, NTRK2, NTRK3, NUP93, NUTM1, PAK1, PAK3, PAK7, PALB2, PARK2, PARP1, PAX3, PAX5, PAX7, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PDPK1, PGR, PHF6, PHOX2B, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLCG2, PLK2, PMAIP1, PMS1, PMS2, PNRC1, POLD1, POLE, PPARG, PPM1D, PPP2R1A, PPP2R2A, PPP6C, PRDM1, PREX2, PRKAR1A, PRKCI, PRKDC, PRSS8, PTCH1, PTEN, PTPN11, PTPRD, PTPRS, PTPRT, QKI, RAB35, RAC1, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RANBP2, RARA, RASA1, RB1, RBM10, RECQL4, REL, RET, RFWD2, RHEB, RHOA, RICTOR, RIT1, RNF43, ROS1, RPS6KA4, RPS6KB1, RPS6KB2, RPTOR, RUNX1, RUNX1T1, RYBP, SDHA, SDHAF2, SDHB, SDHC, SDHD, SETBP1, SETD2, SF3B1, SH2B3, SH2D1A, SHQ1, SLIT2, SLX4, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMARCD1, SMC1A, SMC3, SMO, SNCAIP, SOCS1, SOX10, SOX17, SOX2, SOX9, SPEN, SPOP, SPTA1, SRC, SRSF2, STAG1, STAG2, STAT3, STAT4, STAT5A, STAT5B, STK11, STK40, SUFU, SUZ12, SYK, TAF1, TBX3, TCEB1, TCF3, TCF7L2, TERC, TERT, TET1, TET2, TFE3, TFRC, TGFBR1, TGFBR2, TMEM127, TMPRSS2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TP63, TRAF2, TRAF7, TSC1, TSC2, TSHR, U2AF1, VEGFA, VHL, VTCN1, WISP3, WT1, XIAP, XPO1, XRCC2, YAP1, YES1, ZBTB2, ZBTB7A, ZFHX3, ZNF217, ZNF703, ZRSR2.	LOD 5 %, Tumor Mutation Burden, MSI status
	Fusion - somatic	ABL1, AKT3, ALK, AR, AXL, BCL2, BRAF, BRCA1, BRCA2, CDK4, CSF1R, EGFR, EML4, ERBB2, ERG, ESR1, ETS1, ETV1, ETV4, ETV5, EWSR1, FGFR1, FGFR2, FGFR3, FGFR4, FLI1, FLT1, FLT3, JAK2, KDR, KIF5B, KIT, MET, MLL, MLLT3, MSH2, MYC, NOTCH1, NOTCH2, NOTCH3, NRG1, NTRK1, NTRK2, NTRK3, PAX3, PAX7, PDGFRA, PDGFRB, PIK3CA, PPARG, RAF1, RET, ROS1, RPS6KB1, TMPRSS2

TS500D, TS500P	TSO500 complete DNA mutation and RNA fusion analysis with PanCancer RNA probes			Illumina
	Mutation - somatic	ABL1, ABL2, ACVR1, ACVR1B, AKT1, AKT2, AKT3, ALK, ALOX12B, ANKRD11, ANKRD26, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, BAP1, BARD1, BBC3, BCL10, BCL2, BCL2L1, BCL2L11, BCL2L2, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTK, C11orf30, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD274, CD276, CD74, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CENPA, CHD2, CHD4, CHEK1, CHEK2, CIC, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CSNK1A1, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CUX1, CXCR4, CYLD, DAXX, DCUN1D1, DDR2, DDX41, DHX15, DICER1, DIS3, DNAJB1, DNMT1, DNMT3A, DNMT3B, DOT1L, E2F3, EED, EGFL7, EGFR, EIF1AX, EIF4A2, EIF4E, EML4, EP300, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERG, ERRFI1, ESR1, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EZH2, FAM123B, FAM175A, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FAS, FAT1, FBXW7, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLI1, FLT1, FLT3, FLT4, FOXA1, FOXL2, FOXO1, FOXP1, FRS2, FUBP1, FYN, GABRA6, GATA1, GATA2, GATA3, GATA4, GATA6, GEN1, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GPR124, GPS2, GREM1, GRIN2A, GRM3, GSK3B, H3F3A, H3F3B, H3F3C, HGF, HIST1H1C, HIST1H2BD, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST2H3A, HIST2H3C, HIST2H3D, HIST3H3, HLA-A, HLA-B, HLA-C, HNF1A, HNRNPK, HOXB13, HRAS, HSD3B1, HSP90AA1, ICOSLG, ID3, IDH1, IDH2, IFNGR1, IGF1, IGF1R, IGF2, IKBKE, IKZF1, IL10, IL7R, INHA, INHBA, INPP4A, INPP4B, INSR, IRF2, IRF4, IRS1, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIF5B, KIT, KLF4, KLHL6, KMT2B, KMT2C, KMT2D, KRAS, LAMP1, LATS1, LATS2, LMO1, LRP1B, LYN, LZTR1, MAGI2, MALT1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAP3K14, MAP3K4, MAPK1, MAPK3, MAX, MCL1, MDC1, MDM2, MDM4, MED12, MEF2B, MEN1, MET, MGA, MITF, MLH1, MLL, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MST1, MST1R, MTOR, MUTYH, MYB, MYC, MYCL1, MYCN, MYD88, MYOD1, NAB2, NBN, NCOA3, NCOR1, NEGR1, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NKX3-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NRG1, NSD1, NTRK1, NTRK2, NTRK3, NUP93, NUTM1, PAK1, PAK3, PAK7, PALB2, PARK2, PARP1, PAX3, PAX5, PAX7, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PDPK1, PGR, PHF6, PHOX2B, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLCG2, PLK2, PMAIP1, PMS1, PMS2, PNRC1, POLD1, POLE, PPARG, PPM1D, PPP2R1A, PPP2R2A, PPP6C, PRDM1, PREX2, PRKAR1A, PRKCI, PRKDC, PRSS8, PTCH1, PTEN, PTPN11, PTPRD, PTPRS, PTPRT, QKI, RAB35, RAC1, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RANBP2, RARA, RASA1, RB1, RBM10, RECQL4, REL, RET, RFWD2, RHEB, RHOA, RICTOR, RIT1, RNF43, ROS1, RPS6KA4, RPS6KB1, RPS6KB2, RPTOR, RUNX1, RUNX1T1, RYBP, SDHA, SDHAF2, SDHB, SDHC, SDHD, SETBP1, SETD2, SF3B1, SH2B3, SH2D1A, SHQ1, SLIT2, SLX4, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMARCD1, SMC1A, SMC3, SMO, SNCAIP, SOCS1, SOX10, SOX17, SOX2, SOX9, SPEN, SPOP, SPTA1, SRC, SRSF2, STAG1, STAG2, STAT3, STAT4, STAT5A, STAT5B, STK11, STK40, SUFU, SUZ12, SYK, TAF1, TBX3, TCEB1, TCF3, TCF7L2, TERC, TERT, TET1, TET2, TFE3, TFRC, TGFBR1, TGFBR2, TMEM127, TMPRSS2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TP63, TRAF2, TRAF7, TSC1, TSC2, TSHR, U2AF1, VEGFA, VHL, VTCN1, WISP3, WT1, XIAP, XPO1, XRCC2, YAP1, YES1, ZBTB2, ZBTB7A, ZFHX3, ZNF217, ZNF703, ZRSR2.	LOD 5 %, Tumor Mutation Burden, MSI status
	Fusion - somatic	ABCC3, ABI1, ABL1, ABL2, ABLIM1, ACACA, ACE, ACER1, ACKR3, ACSBG1, ACSL3, ACSL6, ACVR1B, ACVR1C, ACVR2A, ADD3, ADM, AFF1, AFF3, AFF4, AGR3, AHCYL1, AHI1, AHR, AHRR, AIP, AK2, AK5, AKAP12, AKAP6, AKAP9, AKR1C3, AKT1, AKT2, AKT3, ALDH1A1, ALDH2, ALDOC, ALK, AMER1, AMH, ANGPT1, ANKRD28, ANLN, APC, APH1A, APLP2, APOD, AR, ARAF, ARFRP1, ARHGAP20, ARHGAP26, ARHGEF12, ARHGEF7, ARID1A, ARID2, ARIH2, ARNT, ARRDC4, ASMTL, ASPH, ASPSCR1, ASTN2, ASXL1, ATF1, ATF3, ATG13, ATG5, ATIC, ATL1, ATM, ATP1B4, ATP8A2, ATR, ATRNL1, ATRX, AURKA, AURKB, AUTS2, AXIN1, AXL, BACH1, BACH2, BAG4, BAIAP2L1, BAP1, BARD1, BAX, BAZ2A, BCAS3, BCAS4, BCL10, BCL11A, BCL11B, BCL2, BCL2A1, BCL2L1, BCL2L2, BCL3, BCL6, BCL7A, BCL9, BCOR, BCORL1, BCR, BDNF, BHLHE22, BICC1, BIN1, BIRC3, BIRC6, BLM, BMP4, BMPR1A, BRAF, BRCA1, BRCA2, BRD1, BRD3, BRD4, BRIP1, BRSK1, BRWD3, BTBD18, BTG1, BTG2, BTK, BTLA, BUB1B, C11orf1, C11orf30, C11orf54, C11orf95, C2CD2L, C2orf44, C3orf27, CACNA1F, CACNA1G, CACNA2D3, CAD, CALR, CAMK2A, CAMK2B, CAMK2G, CAMTA1, CANT1, CAPRIN1, CAPZB, CARD11, CARM1, CARS, CASC5, CASP3, CASP7, CASP8, CAV1, CBFA2T3, CBFB, CBL, CBLB, CBLC, CCAR2, CCDC28A, CCDC6, CCDC88C, CCK, CCL2, CCNA2, CCNB1IP1, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNG1, CCT6B, CD19, CD22, CD274, CD28, CD36, CD44, CD58, CD70, CD74, CD79A, CD79B, CD8A, CDC14A, CDC14B, CDC25A, CDC25C, CDC42, CDC73, CDH1, CDH11, CDK1, CDK12, CDK2, CDK4, CDK5RAP2, CDK6, CDK7, CDK8, CDK9, CDKL5, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CDX1, CDX2, CEBPA, CEBPB, CEBPD, CEBPE, CENPF, CENPU, CEP170B, CEP57, CEP85L, CHCHD7, CHD2, CHD6, CHEK1, CHEK2, CHIC2, CHL1, CHMP2B, CHN1, CHST11, CHUK, CIC, CIITA, CIRH1A, CIT, CKB, CKS1B, CLP1, CLTA, CLTC, CLTCL1, CMKLR1, CNBP, CNOT2, CNTN1, CNTRL, COG5, COL11A1, COL1A1, COL1A2, COL3A1, COL6A3, COL9A3, COMMD1, COX6C, CPNE1, CPS1, CPSF6, CRADD, CREB1, CREB3L1, CREB3L2, CREBBP, CRKL, CRLF2, CRTC1, CRTC3, CSF1, CSF1R, CSF3, CSF3R, CSNK1G2, CSNK2A1, CTCF, CTDSP2, CTLA4, CTNNA1, CTNNB1, CTNND2, CTRB1, CTSA, CUX1, CXCL8, CXCR4, CXXC4, CYFIP2, CYLD, CYP1B1, CYP2C19, DAB2IP, DACH1, DACH2, DAXX, DCLK2, DCN, DDB2, DDIT3, DDR2, DDX10, DDX20, DDX39B, DDX3X, DDX5, DDX6, DEK, DGKB, DGKI, DGKZ, DICER1, DIRAS3, DIS3L2, DKK1, DKK2, DKK4, DLEC1, DLL1, DLL3, DLL4, DMRT1, DMRTA2, DNAJB1, DNM1, DNM2, DNM3, DNMT1, DNMT3A, DOCK1, DOT1L, DPM1, DPYD, DST, DTX1, DTX4, DUSP2, DUSP22, DUSP26, DUSP9, DUX4, E2F1, EBF1, ECT2L, EDIL3, EDNRB, EED, EEFSEC, EGF, EGFR, EGR1, EGR2, EGR3, EGR4, EIF4A2, EIF4E, ELF4, ELK4, ELL, ELN, ELOVL2, ELP2, EML1, EML4, ENPP2, EP300, EP400, EPC1, EPCAM, EPHA10, EPHA2, EPHA3, EPHA5, EPHA7, EPHB1, EPHB6, EPO, EPOR, EPS15, ERBB2, ERBB3, ERBB4, ERC1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERG, ERLIN2, ESR1, ETS1, ETS2, ETV1, ETV4, ETV5, ETV6, EWSR1, EXOSC6, EXT1, EXT2, EYA1, EYA2, EZH2, EZR, FAF1, FAM127C, FAM19A2, FAM19A5, FAM46C, FAM64A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FASLG, FBN2, FBXO11, FBXO31, FBXW7, FCGBP, FCGR2B, FCRL4, FEN1, FEV, FGF1, FGF10, FGF13, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF6, FGF8, FGF9, FGFR1, FGFR1OP, FGFR1OP2, FGFR2, FGFR3, FGFR4, FH, FHIT, FHL2, FIGF, FIP1L1, FLCN, FLI1, FLNA, FLNC, FLT1, FLT3, FLT3LG, FLT4, FLYWCH1, FNBP1, FOS, FOSB, FOSL1, FOXL2, FOXO1, FOXO3, FOXO4, FOXP1, FRK, FRMPD4, FRS2, FRYL, FSTL3, FUS, FUT1, FZD10, FZD2, FZD3, FZD6, FZD7, FZD8, GAB1, GABRG2, GADD45B, GANAB, GAS1, GAS5, GAS7, GATA1, GATA2, GATA3, GATA6, GBP2, GDF6, GFAP, GHR, GID4, GIT2, GLI1, GLI3, GMPS, GNA11, GNA12, GNA13, GNAI1, GNAQ, GNAS, GNG4, GOLGA5, GOPC, GOSR1, GOT1, GPC3,	LOD: 5 unique reads, EF>5%
		GPHN, GPR124, GPR128, GPR34, GRB10, GRB2, GRHPR, GRID1, GRIN2A, GRIN2B, GRM1, GRM3, GSK3B, GSN, GSTT1, GTF2I, GTSE1, H2AFX, H3F3A, HAS2, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HECW1, HEPH, HERPUD1, HES1, HES5, HEY1, HGF, HHEX, HIF1A, HIP1, HIPK1, HIPK2, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H2AC, HIST1H2AG, HIST1H2AL, HIST1H2AM, HIST1H2BC, HIST1H2BJ, HIST1H2BK, HIST1H2BO, HIST1H3B, HIST1H4I, HLF, HMGA1, HMGA2, HMGB1, HMGN2P46, HNF1A, HNRNPA2B1, HOOK3, HOXA10, HOXA11, HOXA13, HOXA3, HOXA9, HOXC11, HOXC13, HOXD11, HOXD13, HOXD9, HRAS, HSP90AA1, HSP90AB1, HSPA1A, HSPA2, HSPA4, HSPA5, HTRA1, HUWE1, IBSP, ICAM1, ICK, ID1, ID3, ID4, IDH1, IDH2, IFNG, IFRD1, IGF1, IGF1R, IGFBP2, IGFBP3, IKBKB, IKBKE, IKZF1, IKZF2, IKZF3, IL12RB2, IL13, IL13RA2, IL15, IL1B, IL1R1, IL1RAP, IL2, IL21R, IL2RA, IL3, IL6, IL7R, INHBA, INPP4A, INPP4B, INPP5A, INPP5D, IQCG, IRF1, IRF2BP2, IRF4, IRF8, IRS1, IRS2, IRS4, ITGA5, ITGA7, ITGA8, ITGAV, ITGB3, ITK, ITPKA, JAG2, JAK1, JAK2, JAK3, JARID2, JAZF1, JUN, KALRN, KANK1, KAT2B, KAT6A, KAT6B, KCNB1, KDM1A, KDM2B, KDM4C, KDM5A, KDM5C, KDM6A, KDR, KDSR, KEAP1, KIAA0232, KIAA1524, KIAA1549, KIAA1598, KIF5B, KIT, KLF4, KLHL6, KLK2, KLK7, KMT2A, KMT2B, KMT2C, KMT2D, KPNB1, KRAS, KSR1, KTN1, LAMA1, LAMA5, LAMP2, LASP1, LCK, LCP1, LEF1, LEFTY2, LFNG, LGALS3, LGR5, LHFP, LHX2, LHX4, LIFR, LINC00598, LINC00982, LINGO2, LMBRD1, LMO1, LMO2, LMO7, LNP1, LOX, LPAR1, LPP, LPXN, LRIG3, LRMP, LRP1B, LRP5, LRPPRC, LRRC37B, LRRC59, LRRC7, LRRK2, LTBP1, LYL1, LYN, MACROD1, MAD2L1, MADD, MAF, MAFB, MAGED1, MAGEE1, MALAT1, MALT1, MAML1, MAML2, MAP2, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K6, MAP3K7, MAPK1, MAPK3, MAPK8, MAPK8IP2, MAPK9, MAPRE1, MATK, MAX, MB21D2, MBNL1, MBTD1, MCL1, MDC1, MDH1, MDM2, MDM4, MDS2, MEAF6, MECOM, MED12, MEF2B, MEF2C, MEF2D, MELK, MEN1, MET, METTL18, METTL7B, MFNG, MGEA5, MGMT, MIB1, MIPOL1, MITF, MKI67, MKL1, MKL2, MLF1, MLH1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT4, MLLT6, MMP7, MMP9, MN1, MNAT1, MNX1, MPL, MRE11A, MSH2, MSH3, MSH6, MSI2, MSN, MTCP1, MTOR, MTUS2, MUC1, MUTYH, MYB, MYBL1, MYC, MYCL, MYCN, MYD88, MYH11, MYH9, MYO18A, MYO1F, NAB2, NACA, NAPA, NAV3, NBEAP1, NBN, NBR1, NCAM1, NCKIPSD, NCOA1, NCOA2, NCOA3, NCOA4, NCOR2, NCSTN, NDC80, NDE1, NDRG1, NDUFAF1, NEDD4, NEURL1, NF1, NF2, NFATC1, NFATC2, NFE2L2, NFIB, NFKB1, NFKB2, NFKBIA, NGF, NGFR, NIN, NIPBL, NKX2-1, NKX2-5, NOD1, NODAL, NONO, NOS3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NPM2, NR3C1, NR4A3, NR6A1, NRAS, NSD1, NT5C2, NTF3, NTF4, NTRK1, NTRK2, NTRK3, NUMA1, NUP107, NUP214, NUP93, NUP98, NUTM1, NUTM2A, NUTM2B, OFD1, OLIG1, OLIG2, OLR1, OMD, P2RY8, PAFAH1B2, PAG1, PAK1, PAK3, PAK6, PAK7, PALB2, PAPPA, PASK, PATZ1, PAX3, PAX5, PAX7, PAX8, PBRM1, PBX1, PC, PCBP1, PCLO, PCM1, PCNA, PCSK7, PDCD1, PDCD11, PDCD1LG2, PDE4DIP, PDGFA, PDGFB, PDGFD, PDGFRA, PDGFRB, PDK1, PEG3, PER1, PFDN5, PHB, PHF1, PHF23, PHF6, PHOX2B, PI4KA,
		PICALM, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIM1, PKM, PLA2G2A, PLA2G5, PLAG1, PLAT, PLAU, PLCB1, PLCB4, PLCG1, PLCG2, PLEKHM2, PML, PMS1, PMS2, POFUT1, POLD1, POLD4, POLR2H, POM121, POMGNT1, POSTN, POT1, POU2AF1, POU5F1, PPAP2B, PPARG, PPARGC1A, PPFIA2, PPFIBP1, PPM1D, PPP1CB, PPP1R13B, PPP1R13L, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2B, PPP2R4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP4C, PQLC3, PRCC, PRDM1, PRDM16, PRDM7, PRF1, PRG2, PRICKLE1, PRKACA, PRKACG, PRKAR1A, PRKCA, PRKCB, PRKCD, PRKCG, PRKDC, PRKG2, PRMT1, PRMT8, PROM1, PRRX1, PRRX2, PRSS8, PSD3, PSEN1, PSIP1, PSMD2, PTBP1, PTCH1, PTCRA, PTEN, PTGS2, PTK2, PTK2B, PTK7, PTPN11, PTPN2, PTPN6, PTPRA, PTPRK, PTPRO, PTPRR, PTTG1, PVT1, RABEP1, RAC1, RAC2, RAC3, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAF1, RALGDS, RANBP17, RANBP2, RAP1GDS1, RARA, RASAL1, RASGEF1A, RASGRF1, RASGRF2, RASGRP1, RB1, RBM15, RBM6, RCHY1, RCOR1, RCSD1, RECQL4, REEP3, RELA, RELN, RERG, RET, RGS7, RHBDF2, RHOA, RHOD, RHOH, RICTOR, RLTPR, RMI2, RNF213, RNF43, ROBO1, ROBO2, ROS1, RPA3, RPL22, RPN1, RPN2, RPS21, RPS6KA1, RPS6KA2, RPS6KA3, RPTOR, RREB1, RRM1, RRM2B, RTEL1, RTN3, RUNX1, RUNX1T1, RUNX2, RYR3, S1PR2, SARNP, SBDS, SCN8A, SDC4, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC31A, SEPT2, SEPT5, SEPT6, SEPT9, SERP2, SERPINE1, SERPINF1, SET, SETBP1, SETD2, SETD7, SF3B1, SFPQ, SFRP2, SFRP4, SGK1, SGPP2, SH2D5, SH3BP1, SH3D19, SH3GL1, SH3GL2, SHC1, SHC2, SIK3, SIN3A, SIRT1, SKP2, SLC1A2, SLC34A2, SLC45A3, SLC7A5, SLCO1B3, SLX4, SMAD2, SMAD3, SMAD4, SMAD6, SMAP1, SMARCA1, SMARCA4, SMARCA5, SMARCB1, SMC1A, SMC3, SMO, SNAPC3, SNCG, SNHG5, SNW1, SNX29, SNX9, SOCS1, SOCS2, SOCS3, SOD2, SORBS2, SORT1, SOS1, SOX10, SOX11, SOX2, SP1, SP3, SPECC1, SPEN, SPOP, SPP1, SPRY2, SPRY4, SPTAN1, SPTBN1, SQSTM1, SRC, SRF, SRGAP3, SRRM3, SRSF2, SRSF3, SS18, SS18L1, SSBP2, SSX1, SSX2, SSX4, ST6GAL1, STAG2, STAT1, STAT3, STAT4, STAT5A, STAT5B, STAT6, STIL, STK11, STL, STRN, STX5, STYK1, SUFU, SUGP2, SULF1, SUV39H2, SUZ12, SYK, SYP, TACC1, TACC2, TACC3, TAF1, TAF15, TAL1, TAL2, TAOK1, TBL1XR1, TBX15, TCEA1, TCF12, TCF3, TCF7L2, TCL1A, TCL6, TCTA, TEAD1, TEAD2, TEAD3, TEAD4, TEC, TENM1, TERF1, TERF2, TERT, TET1, TET2, TFAP2A, TFDP1, TFE3, TFEB, TFG, TFPT, TFRC, TGFB2, TGFB3, TGFBI, TGFBR2, TGFBR3, THADA, THBS1, THRAP3, TIAM1, TIRAP, TLL2, TLR4, TLX1, TLX3, TMEM127, TMEM230, TMEM30A, TMPRSS2, TNC, TNF, TNFAIP3, TNFRSF10B, TNFRSF10D, TNFRSF11A, TNFRSF14, TNFRSF17, TNFRSF6B, TOP1, TOP2A, TOP2B, TP53, TP53BP1, TP63, TP73, TPD52L2, TPM3, TPM4, TPO, TPR, TRAF2, TRAF3, TRAF5, TRHDE, TRIM24, TRIM27, TRIM33, TRIP11, TRPS1, TSC1, TSC2, TSHR, TTK, TTL, TUSC3, TYK2, TYMS, U2AF1, U2AF2, UBE2B, UBE2C, UFC1, UFM1, USP16, USP42, USP5, USP6, USP7, VCAM1, VEGFA, VEGFC, VGLL3, VHL, VTI1A, WASF2, WDFY3, WDR1, WDR18, WDR70, WDR90, WEE1, WHSC1, WHSC1L1, WIF1, WISP3, WNT10A, WNT10B, WNT11, WNT16, WNT2B, WNT3, WNT4, WNT5B, WNT6, WNT7B, WNT8B, WRN, WSB1, WT1, WWOX, WWTR1, XBP1, XIAP, XKR3, XPA, XPC, XPO1, XRCC6, YAP1, YPEL5, YTHDF2, YWHAE, YY1AP1, ZBTB16, ZC3H7A, ZC3H7B, ZFP64, ZFPM2, ZFYVE19, ZIC2, ZMIZ1, ZMYM2, ZMYM3, ZMYND11, ZNF207, ZNF217, ZNF24, ZNF331, ZNF384, ZNF444, ZNF521, ZNF585B, ZNF687, ZNF703, ZRSR2

UST	Archer® FusionPlex Universal Solid tumor custom Biopticka			ArcherDX
	Fusion - somatic	CSF1, NOTCH2, NTRK1, AKT3, FGR, MEAF6, MAST2, CAMTA1, PRKACB, MGEA5, FGFR2, EPC1, RET, MSMB, YAP1, PDGFD, PRDM10, MYOD1, ESRRA, RELA, CCND1, MAML2, ETV6, STAT6, GLI1, HMGA2, MDM2, FOXO1, AKT1, PRKD1, RAD51B, NUTM1, TCF12, MAP2K1, NTRK3, IGF1R, MKL2, PRKCB, FUS, PHKB, YWHAE, TAF15, ERBB2, GRB7, ETV4, MBTD1, USP6, PRKCA, SS18, MAST1, PRKACA, PKN1, DNAJB1, BRD4, JAK3, CRTC1, GPI, AKT2, NUMBL, AXL, CIC, PRKD2, CHMP2A, INSR, PAX8, ACVR2A, NFE2L2, ERBB4, PAX3, NCOA1, ALK, PRKD3, THADA, NCOA3, NFATC2, SS18L1, ERG, TMPRSS2, MN1, EWSR1, PDGFB, TFG, PPARG, RAF1, RAB7A, WWTR1, PIK3CA, ETV5, PRKCD, EGF, FGFR3, PDGFRA, KIT, TERT, FGF1, ARHGAP26, CSF1R, PDGFRB, VGLL2, ROS1, RSPO3, MYB, ESR1, PHF1, TFEB, MET, ETV1, BRAF, JAZF1, EGFR, RSPO2, MYC, NRG1, FGFR1, PLAG1, MYBL1, NCOA2, NR4A3, MUSK, BRD3, NOTCH1, NFIB, VCP, JAK2, CD274, NTRK2, ARHGAP6, BCOR, TFE3, CCNB3, AR, FOXO4, FOSB, FOS, PTEN, MDM4, GFI1B, CALCA, DDX3X, VGLL3, BCORL1, GLI2, SMARCB1, RB1, PTPN1, GFI1, TTYH1, MAP3K3, CHMP2B, CDK4, MITF, KMT2A, FN1, PTH, TSC2, PRDM6, GNAS, TTF1, MAP3K8, SRF, KRT20, SLC5A5, C11orf95, KRT7, PIP4K2A, RPS19, SMARCA4, MTG1, SERPINE1, NOTCH3	LOD:3 unique starting sites, 5 unique reads, EF>5%

AST	The Archer® FusionPlex® Solid Tumor Kit			ArcherDX
	Fusion - somatic	AKT3, EWSR1, NOTCH1/2, RAF1, ALK, FGFR1/2/3, NRG1, RELA, ARHGAP26, FGR, NTRK1/2/3, RET, AXL, INSR, NUMBL, ROS1, BRAF, MAML2, NUTM1, RSPO2/3, BRD3/4, MAST1/2, PDGFRA/B, TERT, EGFR, MET, PIK3CA, TFE3, ERG, MSMB, PKN1, TFEB, ESR1, MUSK, PPARG, THADA, ETV1/4/5/6, MYB, PRKCA/B, TMPRSS2,	LOD:3 unique starting sites, 5 unique reads, EF>5%
	Mutation - somatic	BRAF, EGFR, MET, PDGFRA	LOD: DEPTH > 50, TAF>5%

LYM	The Archer® FusionPlex® Lymphoma Kit			ArcherDX
	Fusion - somatic	ALK, BCL2, BCL6, BCR, BIRC3, CBFB, CCND1, CCND3, CDK6, CHIC2, CIITA, CREBBP, DEK, DUSP22, EIF4A1, ETV6, FGFR1, JAK2, KMT2A, MALT1, MKL1, MLF1, MLLT10, MYC, NFKB2, NOTCH1, P2RY8, PDCD1LG2, PDGFRA, PRDM16, STIL, TCF3, TP63	LOD:3 unique starting sites, 5 unique reads, EF>5%
	Mutation - somatic	AKT3, ALK, BAX, BCL2, BIRC3, BRAF, BTK, CARD11, CCND1, CD79B, CREBBP, DNMT3A, ETV6, EZH2, FBXW7, IDH1, IDH2, JAK1, JAK2, JAK3, KRAS, MYD88, NOTCH1, NOTCH2, NRAS, PDGFRA, PLCG1, PLCG2, RHOA, SF3B1, STAT3, STAT5B, STAT6, WT1, XPO1	LOD: DEPTH > 50, TAF>5%

LUNG	FusionPlex® Lung v2 Kit, for Illumina
	Mutation - somatic	ALK, BRAF, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, KRAS, NTRK1, NTRK2, NTRK3, PIK3CA, RET, ROS1	LOD: DEPTH > 50, TAF>5%	ArcherDX
	Fusion - somatic	ALK, BRAF, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, MET, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PIK3CA, RET, ROS1	LOD:3 unique starting sites, 5 unique reads, EF>5%

CTL	The Archer® FusionPlex® Comprehensive Thyroid & Lung Kit			ArcherDX
	Fusion - somatic	ALK, AXL, BRAF, BRAF, CCND1, FGFR1, FGFR2, FGFR3, MET, NRG1, NTRK1, NTRK2, NTRK3, PPARG, RAF1, RET, ROS1, THADA	LOD:3 unique starting sites, 5 unique reads, EF>5%
	Mutation - somatic	AKT1, ALK, AXL, BRAF, CTNNB1, DDR2, EGFR, ERBB2, GNAS, HRAS, IDH1, IDH2, KRAS, MAP2K1, NRAS, PIK3CA, RET, ROS1, EGFR, MET	LOD: DEPTH > 50, TAF>5%
	Expression	ALK, AXL, BRAF, CCND1, EGFR, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK2, NTRK3, RET, ROS1, THADA, CALC, KRT20, KRT7, PTH, SLC5A5, TTF1

MYE	Archer FusionPlex MyeloidKit			ArcherDX
	Fusion - somatic	ABL1, BCR, CBFB, CHD1, CHIC2, CREBBP, CSF1R, ERG, ETV6, ETV6, FGFR1, FGFR1, GLIS2, IKZF3, JAK2, JAK2, KAT6A, KMT2A, KMT2A, MECOM, MKL1, MLLT10, MLLT10, MLLT4, MYC, MYH11, NF1, NF1, NOTCH1, NOTCH1, NUP214, NUP98, NUP98, PDCD1L, PDCD1L, PDGFRA, PDGFRB, PICALM, PML, PML, RARA, RBM15, ROS1, RUNX1, RUNX1, RUNX1T1, SETD2, TCF3, TFG	LOD:3 unique starting sites, 5 unique reads, EF>5%
	Mutation - somatic	ABL1, AKT3, ASXL1, BRAF, CALR, CBL, CEBPA, CREBBP, CSF3R, DCK, DNM2, DNMT3A, ETV6, EZH2, FBXW7, FGFR2, FGFR3, FLT3, GATA1, GATA2, GNAS, IDH1, IDH2, IKZF3, JAK1, JAK2, JAK3, KDM6A, KIT, KRAS, MPL, MYD88, NOTCH1, NPM1, NRAS, PDGFRA, PHF6, PML, PTPN11, RARA, SETBP1, SF3B1, SLC29A1, SRSF2, U2AF1, WT1, XPO1	LOD: DEPTH > 50, TAF>5%

CoReLu	The Archer VariantPlex™ Custom Solid Tumor Kit			ArcherDX
	Mutation - somatic	KEAP1, ALK, ATM, NTRK1, NF1, MTOR, ARAF, NTRK3, ERBB2, EGFR, CDKN2A, PIK3CA, STK11, FGFR1, MAP2K1, NTRK2, PTEN, FGFR3, MET, BRAF, CDK12, KRAS, TP53, FGFR2, CDKN2A, CDKN2A, DDR2, RET, ATM, AKT1, CDK12, FGFR1, NTRK1, NTRK3, EGFR, NTRK3, NTRK2, FGFR3, NRAS, FGFR1, CDKN2A, FGFR2, NF1, EGFR, NTRK2, FGFR1, FGFR2, TP53, NF1, FGFR2, RET, EGFR, KRAS, MET.	LOD 5 %

VST	The Archer VariantPlex™ Solid Tumor Kit			ArcherDX
	Mutation - somatic	ABL1, AKT1, ALK, APC, ATM, AURKA, BRAF, CCND1, CCNE1, CDH1, CDK4, CDKN2A, CSF1R, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ESR1, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, FOXL2, GNA11, GNAQ, GNAS, H3F3A, HNF1A, HRAS, IDH1, IDH2, JAK2, JAK3, KDR, KIT, KRAS, MAP2K1, MDM2, MET, MLH1, MPL, MYC, MYCN, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PIK3R1, PTEN, PTPN11, RB1, RET, RHOA, ROS1, SMAD4, SMARCB1, SMO, SRC, STK11, TERT, TP53, VHL	LOD 5 %

VCTL	The Archer VariantPlex™ CTL (Lunng/Thyroid)		LOD 5 %	ArcherDX
	Mutation - somatic	AKT1, ALK, BRAF, CCND1, CTNNB1, DDR2, EGFR, EIF1AX, ERBB2, FGFR1, FGFR2, FGFR3, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MAP2K1, MDM2, MET, NRAS, PDGFRA, PIK3CA, PTEN, RET, ROS1, STK11, TERT, TP53, TSHR

MYE core	The Archer VariantPlex™ Core Myeloid Kit			ArcherDX
	Mutation - somatic	ABL1, ANKRD26, ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DDX41, DNMT3A, ETNK1, ETV6, EZH2, FLT3, GATA1, GATA2, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NPM1, NRAS, PHF6, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2	LOD 5 %

SWIFT	Accel-Amplicon EGFR Pathway Panel			IDT
	Mutation - somatic	EGFR, KRAS, NRAS, BRAF	LOD 5 %

VOLA	VariantPlex® BRCA v2 Kit			ArcherDX
	Mutation - somatic	BRCA1, BRCA2	LOD 10 %

VGYN	VariantPlex Biopticka GynCore custom kit			ArcherDX
	Mutation - somatic	BRCA1, BRCA2, BCOR, MLH1, MSH2, MSH6, PMS2, NRAS, TP53, POLE, POLD1, ARID1A, CTNNB1, KRAS, PIK3CA, PTEN	LOD 5 %

KHP	Kappa Hyper Plus			Kapa
	Mutation - somatic	Any PCR product	LOD 5 %

	CNV detection using Low Pass Genome sequencing
LPG	CNV detection			IDT
	CNV - somatic	Chromosomal abberations (duplications and deletions of parts or whole chromosomes) in whole genome available for blood or FFPE samples	LOD: size of the detected CNV >100MBp, sample purity >30% of aberrant tissue, polyploidy not detectable.

	TCR/Ig clonality, muation, fusion, CNV
EuroClonality NGS (UNIV8)	mutation	ARID1A, ATM, B2M, BCL2, BTG1, BTK, CDKN2A, CDKN2B, CDKN2C, CKS1B, EP300, ERG, FAT1, H1-5, H1-2, H1-3, H1-4, ID3, KLF2, KMT2D, MAP3K14, MAPK1, MYC, PAX5, PHF6, POT1, PTEN, PTPRD, RHOA, RUNX1, SAMHD1, SOCS1, TCF3, TENT5C, TET2, TNFAIP3, TP53, TRAF2, TRAF3, WT1, ABL1, ASXL1, BIRC3, BRAF, CARD11, CCND1, CCND3, CD79A, CD79B, CREBBP, CXCR4, DIS3, DNMT3A, EGR2, EZH2, FBXW7, FOXO1, IDH1, IDH2, IKZF1, IL7R, IRF4, JAK1, JAK2, JAK3, KIT, KRAS, MAP2K1, MEF2B, MYD88, NFKBIE, NOTCH1, NOTCH2, NRAS, NT5C2, PIK3CA, PLCG1, PLCG2, SF3B1, STAT3, STAT5B, STAT6, XPO1	LOD 5 %	Univ8 genomics
	fusion	STIL, ALK, BCL6, DUSP22, MYC, CD274, PDCDlLG2, CCNDI, BIRC3, KMT2A, BCL2, TCF3, CRLF2	LOD 5 %
	CNV	9pTEL, 13qMDRa, 9pCEN, 13qTEL, 11qCEN, 17pTEL, 11qTEL, 17pCEN, RB1	LOD 40 %
	clonality Ig/TCR	IgH, IgK, IgL, TCRA, TCRB, TCRD, TCRG	LOD 5 %

Liquid biopsy (mutation testing in patient`s blood) by NGS
MSK Access (MSK-LB)	MSK-Access® kit (Sophia Genetics™)			Sophia Genetics
	Detection of somatic hotspot mutations in genes (see 1), CNVs in genes (see 2), and gene fusions (see 3) using the MSK-Access® kit (Sophia Genetics™) with massively parallel sequencing (NGS). Evaluated using SOPHIA DDM™ software. LOD for variants: SNVs/INDELs: AF: 0,5%; CNVs: ≥2.95 amplification and ≤1.35 deletion; fusions: ≥3 unique copies.*	*1 - SNV a INDEL/DELIN: AKT1 (3, 6, 7, 8, 9, 10, 11, 12), ALK (5, 9, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29), APC (full CDS), AR (full CDS), ARAF (7, 10, 11, 12, 13, 14, 15, 16), ARID1A (full CDS), ARID2 (8), ASXL1 (full CDS), ATM (full CDS), B2M (1), BAP1 (full CDS), BCL2 (2), BCOR (10), BRAF (11, 12, 13, 14, 15, 16, 17, 18), BRCA1 (full CDS), BRCA2 (full CDS), CARD11 (13), CBFB (2), CBL (9), CCND1 (5), CD79B (5), CDH1 (full CDS), CDK12 (full CDS), CDK4 (full CDS), CDKN2A (full CDS), CHEK2 (full CDS), CIC (5), CREBBP (26, 27, 30), CTCF (6), CTNNB1 (3, 7, 8), DICER1 (27), DIS3 (10), DNMT3A (full CDS), EGFR (3, 6, 7, 15, 18, 19, 20, 21, 22, 23, 24), EIF1AX (1, 2), EP300 (26, 27), ERBB2 (3, 6, 7, 8, 12, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27), ERBB3 (3, 6, 7, 8, 9, 18, 19, 20, 21, 22, 23, 24), ERCC2 (full CDS), ESR1 (6, 7, 8, 9), EZH2 (16), FBXW7 (full CDS), FGFR1 (12, 13, 14, 15, 16, 17, 18, 19), FGFR2 (3, 5, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18), FGFR3 (7, 9, 11, 12, 13, 14, 15, 16, 17, 18), FGFR4 (13), FLT3 (14, 20), FOXA1 (2), FOXL2 (full CDS), FOXO1 (1), FOXP1 (14), FUBP1 (14), GATA3 (full CDS), GNA11 (5), GNAQ (5), GNAS (6, 8, 9), H3F3A (2), HIST1H3B (full CDS), HRAS (2, 3, 4), IDH1 (4, 5), IDH2 (4), IKZF1 (8), INPPL1 (2), JAK1 (19), JAK2 (14), KDM6A (full CDS), KEAP1 (full CDS), KIT (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), KNSTRN (1), KRAS (full CDS), MAP2K1 (2, 3, 4, 5, 6, 7, 8, 9, 10, 11), MAP2K2 (2, 3, 4, 5, 6, 7, 8, 9, 10, 11), MAPK1 (7), MAX (2, 4), MED12 (2, 26), MET (13, 14, 15, 16, 17, 18, 19, 20, 21), MLH1 (full CDS), MSH2 (full CDS), MSH3 (7), MSH6 (full CDS), MTOR (29, 30, 31, 39, 40, 43, 44, 46, 47, 48, 49, 50, 53, 56, 57), MYC (2), MYCN (2), MYD88 (5), MYOD1 (1), NF1 (full CDS), NFE2L2 (2), NOTCH1 (6, 8), NPM1 (11), NRAS (2, 3, 4), NTRK1 (13, 14, 15, 16, 17), NTRK2 (15, 16, 17, 18, 19), NTRK3 (15, 16, 17, 18, 19, 20), NUP93 (2), PAK5 (4), PALB2 (full CDS), PDGFRA (5, 6, 7, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), PHF6 (5, 9), PIK3CA (2, 3, 5, 6, 8, 9, 10, 11, 12, 14, 19, 20, 21), PIK3CB (24), PIK3R1 (10, 11, 13, 14), PIK3R2 (10), PIM1 (1), PMS2 (full CDS), POLE (1, 9, 13), POT1 (6), PPM1D (full CDS), PPP2R1A (5, 6), PPP6C (7), PRKCI (15), PTCH1 (full CDS), PTEN (full CDS), PTPN11 (3, 13), RAC1 (2), RAD54L (10), RAF1 (7, 10, 11, 12, 13, 14, 15, 16, 17), RB1 (full CDS), RET (8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19), RHOA (2, 3), RIT1 (5), ROS1 (36, 37, 38, 39, 40, 41, 42), RRAS2 (1, 3), RXRA (10), SETD2 (7), SF3B1 (14, 15, 18), SMAD3 (6), SMAD4 (full CDS), SMARCA4 (19, 25, 26), SMARCB1 (9), SOS1 (5), SPOP (4, 5), SRSF2 (1), STAT3 (20), STK11 (full CDS), STK19 (1), TCF7L2 (14), TET2 (full CDS), TGFBR1 (4, 9), TGFBR2 (8), TP53 (full CDS), TP63 (9, 14), TSC1 (full CDS), TSC2 (full CDS), U2AF1 (2, 6), VHL (full CDS), XPO1 (15)	LOD 0,5 %
		2 - CNV: AKT1, ALK, APC, AR, ARAF, ARID1A, ASXL1, ATM, BAP1, BRAF, BRCA1, BRCA2, CDH1, CDK12, CDK4, CDKN2A, CHEK2, CREBBP, DNMT3A, EGFR, EP300, ERBB2, ERBB3, ERCC2, ESR1, FBXW7, FGFR1, FGFR2, FGFR3, FOXA1, FOXL2, GATA3, KDM6A, KEAP1, KIT, KRAS, MAP2K1, MAP2K2, MET, MLH1, MSH2, MSH6, MTOR, MYC, MYCN, NF1, NTRK1, NTRK2, NTRK3, PAK5, PALB2, PDGFRA, PIK3CA, PIK3R1, PMS2, PPM1D, PTCH1, PTEN, RAF1, RB1, RET, ROS1, SF3B1, SMAD4, SMARCA4, STK11, TET2, TP53, TSC1, TSC2, VHL	LOD CNVs: ≥2.95 amplification
		3 - Fusion: ALK (17, 18, 19), BRAF (7, 8, 9, 10), EGFR (7, 17, 24, 25, 26), ETV6 (4, 5), FGFR2 (16, 17), FGFR3 (15, 16, 17, 18), MET (13, 14), NTRK1 (3, 7, 8, 9, 10, 11, 12), RET (7, 8, 9, 10, 11), ROS1 (30, 31, 32, 33, 34, 35)	LOD fusions: ≥3 unique copies

Microbiology NGS
Microbiome	Microbiome sequencing		LOD NA	Integrated DNA Technologies
	Any microorganism with 16S rRNA	sequencing of DNA encoding 16S rRNA

Methylation analysis chip
INF	InfiniumMethylation EPICbeadChip kit	Targets 850,000 CpGs. Quantitatively interrogates selected methylation sites across the genome.	LOD 10-20 %	Illumina


Sanger sequencing
	IDH1 + IDH2	sequencing of exons 4 of IDH1 and IDH2	LOD 10 %, **	LDT
	TERT	mutation promotor region by sequencing	LOD 10 %, **	LDT

Mutation by Real-Time PCR
	Thrombophylic mutation - F2, F5	real time PCR, test CE‐IVD	LOD NA, **	Generi Biotech
	Celiac disease - HLA DQ2, DQ8	real time PCR, test CE‐IVD	LOD NA, **	Elisabeth Pharmacon
	F13, MTHFR, PAI-1	real time PCR, test CE‐IVD	LOD NA, **	Generi Biotech
	BRAF / NRAS (FFPE) - CRC	real time PCR; Idylla™ NRAS/BRAF Mutation Test CE‐IVD	LOD from 1 %, **	Biocartis
	KRAS (FFPE) - CRC	real time PCR; Idylla™ KRAS Mutation Test CE‐IVD	LOD from 1 %, **	Biocartis
	EGFR (FFPE)	real time PCR; Idylla™ EGFR Mutation Test CE‐IVD	LOD from 1 %, **	Biocartis
	MSI (FFPE)	real time PCR; Idylla™ MSI Mutation Test CE‐IVD	LOD 20 %, **	Biocartis
	HFE - codons 63,63,282	real time PCR; gb GENETIC HFE Test CE‐IVD	LOD NA, **	Generi Biotech
	PsorX	real-time PCR; PsorX-LabDisk CE-IVD	LOD NA, **	Dermagnostix

Mutation by LAMP
	metabolic activity of DPY (blood, plasma, DNA)	mutation in DPYD gen using Loop-Mediated Isothermal Amplification	**	Lacar

Translocation/Targeted fusioun transcript analysis / deletion / amplification
	19q13/19p13 (enumeration)	FISH	ratio 0,7	ZytoVision Gmbh
	1p36/1q25 (enumeration)	FISH	ratio 0,7	ZytoVision Gmbh
	ALK 2p23 (break-apart)	FISH	≥15%	HealthCare Biotechnology Co., Ltd.
	BCL2 18q21 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	BCL6 3q27 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	BIRC3 (API2) / MALT1 t(11;18) (fusion)	FISH	≥20%	HealthCare Biotechnology Co., Ltd.
	CCND1 11q13 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	CCND1/IGH t(11;14) (fusion)	FISH	≥20%	HealthCare Biotechnology Co., Ltd.
	CDKN2A / CEP 9 9p21 (enumeration)	FISH	≥30%	HealthCare Biotechnology Co., Ltd.
	CSF1 1p13.3 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	DEK 6p22.2 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	EGFR/CEN 7 7p12 (enumeration)	FISH	EGFR ≥2; CEP7 ≥3 copies >10%	Abbott Molecular
	ERG 21q22.2 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	ETV6 12p13 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	EWSR1 22q12.2 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	FLI1 11q24.3 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	FUS 16p11 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	HER2/CEN 17 17q12 (enumeration)	FISH	viz USCAP guidelines 2023	HealthCare Biotechnology Co., Ltd.
	HMGA2 12q15 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	IGH 14q32.33 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	IGH/BCL2 t(14,18) (fusion)	FISH	≥20%	HealthCare Biotechnology Co., Ltd.
	IGH/MYC t(8;14) (fusion)	FISH	≥20%	HealthCare Biotechnology Co., Ltd.
	IRF4 6p25 (brak-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	MALT1 18q21 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	MAML2 11q21 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	MDM2/CEN 12 12q14.3-q15 (enumeration)	FISH	≥2	HealthCare Biotechnology Co., Ltd.
	MYB 6q23.3 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	MYBL1 8q13.1 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	MYC 8q24.21 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	MYC 8q24.21 (enumeration)	FISH	≥2	HealthCare Biotechnology Co., Ltd.
	MYCN 2p24.3 (enumeration)	FISH	≥2	HealthCare Biotechnology Co., Ltd.
	NR4A3 9q22 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	PDGFB 22q13 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	PHF1 6p21.3 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	PLAG1 8q12 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	PTEN / CEP10 10q23 (enumeration)	FISH	>50%	HealthCare Biotechnology Co., Ltd.
	ROS1 6q22.1 (break-apart)	FISH	≥15%	HealthCare Biotechnology Co., Ltd.
	TFE3 Xp11.23 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	TFEB 6p21 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.
	TFEB 6p21 (enumeration)	FISH	>10 copies in ≥20%	HealthCare Biotechnology Co., Ltd.
	USP6 17p13 (break-apart)	FISH	≥10%	HealthCare Biotechnology Co., Ltd.

Microbiology
	Bartonella spp.	PCR	*LOD ≥10 organisms/reaction	LDT
	Borrelia burgdorferi	nested PCR	*LOD ≥1 organisms/reaction	LDT
	Brucella spp.	PCR	*LOD ≥10 organisms/reaction	LDT
	Chlamydophyla psittaci	PCR	*LOD ≥1 organisms/reaction	LDT
	Chlamydia trachomatis	PCR	*LOD ≥1 organisms/reaction	LDT
	Francisella tularensis	real-time PCR	LOD ≥10 organisms/reaction	LDT
	Listeria spp.	PCR	*LOD ≥10 organisms/reaction	LDT
	Leishmania spp.	PCR	*LOD ≥10 organisms/reaction	LDT
	Mycobacterium spp.	nested PCR	*LOD ≥1 organisms/reaction	LDT
	Mycobacterium tuberculosis complex	nested PCR	*LOD ≥1 organisms/reaction	LDT
	Treponema pallidum	real-time PCR	LOD ≥10 organisms/reaction	LDT
	Tropheryma whipplei	semi-nested PCR	*LOD ≥10 organisms/reaction	LDT
	Yersinia enterocilitica	nested PCR	*LOD ≥10 organisms/reaction	LDT
	Yersinia pseudotuberculosis	PCR	*LOD ≥10 organisms/reaction	LDT
	Respiratory pathogens - bacteria	real-time PCR, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, Haemophilus influenzae, Streptococcus pneumoniae, Bordetella pertussis, Bordetella parapertussis	*LOD ≥100 organisms/reaction	Seegene

Virology
	Adenovirus	real-time quantitative PCR	LOD ≥10 organisms/reaction	R-gene
	BK-JC virus	real-time PCR	LOD ≥10 organisms/reaction	LDT
	BKV	real-time quantitative PCR	LOD ≥10 organisms/reaction	R-gene
	CMV	real-time quantitative PCR	LOD ≥10 organisms/reaction	R-gene
	EBER	in-situ hybridization	LOD ≥1 organisms/slide	Roche
	EBV	real-time PCR	LOD ≥10 organisms/reaction	LDT
	Enterovirus	real-time quantitative PCR	LOD ≥10 organisms/reaction	LDT
	HHV-6	real-time PCR	*LOD ≥10 organisms/reaction	LDT
	HHV-8	PCR	*LOD ≥10 organisms/reaction	LDT
	HPV-HR/LR	PCR	*LOD ≥1184 organisms/reaction	LDT
	HPV - exact type	multiplex real-time PCR and sequencing	LOD ≥1184 organisms/reaction	Seegene
	HSV-1	real-time PCR	LOD ≥10 organisms/reaction	LDT
	HSV-2	real-time PCR	LOD ≥10 organisms/reaction	LDT
	Merkel cell polyomavirus	real-time PCR	LOD ≥10 organisms/reaction	LDT
	Molluscum contagiosum virus	PCR	*LOD ≥10 organisms/reaction	LDT
	Parvovirus B19	real-time quantitative PCR	LOD ≥10 organisms/reaction	R-gene
	HPV E6-E7 type 16,18,31,33,35,45	PCR	LOD ≥1000 organisms/reaction	LDT
	Varicella zoster	real-time PCR	LOD ≥10 organisms/reaction	LDT
	Respiratory pathogens - viruses 1	real-time PCR, Influenza virus A (H1, H3 a H1pdm09), Influenza virus B, RSV A, RSV B	LOD ≥100 organisms/reaction	Seegene
	Respiratory pathogens - viruses 2	real-time PCR, Adenovirus, Metapneumovirus, Enterovirus a Parainfluenza virus 1- 4	LOD ≥100 organisms/reaction	Seegene
	Respiratory pathogens - viruses 3	real-time PCR, Bocavirus, Rhinovirus, Coronavirus NL63, Coronavirus 229E, Coronavirus OC43	LOD ≥100 organisms/reaction	Seegene
	SARS-CoV-2	real-time PCR	LOD ≥100 organisms/reaction	Seegene, Zybio

Parazitology	Echinococcus granulosus / multilocularis	PCR	*LOD ≥10 organisms/reaction	LDT
	Leishmania spp.	PCR	*LOD ≥10 organisms/reaction	LDT
	Toxoplasma spp.	PCR	*LOD ≥10 organisms/reaction	LDT

Mycology		PCR and sequencing (ITS rDNA)	LOD ≥10 organisms/reaction	LDT

Clonality	clonality IgK/IgL	BIOMED-2 PCR and fragment analysis	LOD 5-10 %	LDT
	clonality IgH/IgK/IgL	BIOMED-2 PCR and fragment analysis	LOD 5-10 %	LDT
	clonality IgH	BIOMED-2 PCR and fragment analysis	LOD 5-10 %	LDT
	clonality TCRb/TCRg	BIOMED-2 PCR and fragment analysis	LOD 1-5 %	LDT

Others
	OncoMate™ MSI Dx	fragment analysis - microsatellite instability	LOD 20 %	Promega
	methylation of MGMT promotor	methylation specific PCR	LOD 10 %	LDT
	methylation of MLH1 promotor	methylation specific PCR	LOD 10 %	LDT
	OMNI - Omniplex for Molar preganancy	Super STaR Optima - STR markers (13,18,21,X,Y)	LOD 30 %	Cybergene AB

Prenatal screening
	Anuepoidy 13, 18, 21, XY, triploidy, vanishing twin	PANORAMA test	LOD 2,8 %	NATERA
	Anuepoidy 13, 18, 21, XY, triploidy, vanishing twin+DiGeorge (del22q)	PANORAMA test	LOD 2,8 %	NATERA
	Anuepoidy 13, 18, 21, XY, triploidy, vanishing twin + microdeletion panel	PANORAMA test	LOD 2,8 %	NATERA

Nucleid acid extraction and quality control
	DNA extraction and control genes	QIAsymphony DSP DNA kit + PCR LDT		QIAgen
	RNA extraction and control genes	Maxwell RSC RNA FFPE Kit + PCR LDT		Promega
	DNA quality control - for special purposes	FFPE DNA QC kit - qPCR-based quality control (delta Ct value)		Illumina
	RNA quality control - for special purposes	RNA ScreenTape - electophoresis and DV200 analysis on 2200 TapeStation system		Agilent

Clinical report	Report for Mutation or fusion of 50/250/500 genes	For in vitro examination of next-generation sequencing (NGS) data or genetic and molecular alteration data to provide information to aid in the determination of treatment options based on genetic biomarkers and medical guidelines	price depends on the panel	Molecular Health GmbH

* = positive samples confirmed by Sanger sequencing
** = good quality of nucleic acid required
LOD - limit of detection
NA - not aplicable